The calculated distance (air line) between San Mateo Ixtatán and Zacapa is approximately 143 miles respectively 230 kilometers.
By car or train, the actual journey to Zacapa is certainly longer, as only the direct route (as the crow flies) between San Mateo Ixtatán and Zacapa has been calculated here.
Air line (approximately)
230 kilometers
124 nautical miles