The calculated distance (air line) between Santo Domingo de los Colorados and Portoviejo is approximately 104 miles respectively 168 kilometers.
By car or train, the actual journey to Portoviejo is certainly longer, as only the direct route (as the crow flies) between Santo Domingo de los Colorados and Portoviejo has been calculated here.
Air line (approximately)
168 kilometers
91 nautical miles