The calculated distance (air line) between Santiago Tlacotepec and Iztapalapa is approximately 41 miles respectively 65 kilometers.
By car or train, the actual journey to Iztapalapa is certainly longer, as only the direct route (as the crow flies) between Santiago Tlacotepec and Iztapalapa has been calculated here.
Air line (approximately)
65 kilometers
35 nautical miles