The calculated distance (air line) between Santiago Tlacotepec and Acapulco de Juárez is approximately 165 miles respectively 266 kilometers.
By car or train, the actual journey to Acapulco de Juárez is certainly longer, as only the direct route (as the crow flies) between Santiago Tlacotepec and Acapulco de Juárez has been calculated here.
Air line (approximately)
266 kilometers
143 nautical miles