The calculated distance (air line) between Santiaguito Tlalcilalcalli and Mexico City is approximately 40 miles respectively 64 kilometers.
By car or train, the actual journey to Mexico City is certainly longer, as only the direct route (as the crow flies) between Santiaguito Tlalcilalcalli and Mexico City has been calculated here.
Air line (approximately)
64 kilometers
34 nautical miles