The calculated distance (air line) between Iztapalapa and Pátzcuaro is approximately 166 miles respectively 268 kilometers.
By car or train, the actual journey to Pátzcuaro is certainly longer, as only the direct route (as the crow flies) between Iztapalapa and Pátzcuaro has been calculated here.
Air line (approximately)
268 kilometers
144 nautical miles