The calculated distance (air line) between Mezőhegyes and Nyíregyháza is approximately 121 miles respectively 195 kilometers.
By car or train, the actual journey to Nyíregyháza is certainly longer, as only the direct route (as the crow flies) between Mezőhegyes and Nyíregyháza has been calculated here.
Air line (approximately)
195 kilometers
105 nautical miles