The calculated distance (air line) between Santo Domingo Oeste and Santa Cruz de El Seibo is approximately 66 miles respectively 105 kilometers.
By car or train, the actual journey to Santa Cruz de El Seibo is certainly longer, as only the direct route (as the crow flies) between Santo Domingo Oeste and Santa Cruz de El Seibo has been calculated here.
Air line (approximately)
105 kilometers
57 nautical miles