The calculated distance (air line) between Sezimovo Ústí and Karlovy Vary is approximately 100 miles respectively 161 kilometers.
By car or train, the actual journey to Karlovy Vary is certainly longer, as only the direct route (as the crow flies) between Sezimovo Ústí and Karlovy Vary has been calculated here.
Air line (approximately)
161 kilometers
87 nautical miles