The calculated distance (air line) between Santo Domingo de Guzmán and Iztapalapa is approximately 50 miles respectively 80 kilometers.
By car or train, the actual journey to Iztapalapa is certainly longer, as only the direct route (as the crow flies) between Santo Domingo de Guzmán and Iztapalapa has been calculated here.
Air line (approximately)
80 kilometers
43 nautical miles