The calculated distance (air line) between Santo Domingo de Guzmán and Coyoacán is approximately 44 miles respectively 70 kilometers.
By car or train, the actual journey to Coyoacán is certainly longer, as only the direct route (as the crow flies) between Santo Domingo de Guzmán and Coyoacán has been calculated here.
Air line (approximately)
70 kilometers
38 nautical miles