The calculated distance (air line) between Santo Domingo de los Colorados and Esmeraldas is approximately 90 miles respectively 145 kilometers.
By car or train, the actual journey to Esmeraldas is certainly longer, as only the direct route (as the crow flies) between Santo Domingo de los Colorados and Esmeraldas has been calculated here.
Air line (approximately)
145 kilometers
78 nautical miles