The calculated distance (air line) between San Isidro de Curuguaty and Asunción is approximately 135 miles respectively 217 kilometers.
By car or train, the actual journey to Asunción is certainly longer, as only the direct route (as the crow flies) between San Isidro de Curuguaty and Asunción has been calculated here.
Air line (approximately)
217 kilometers
117 nautical miles