The calculated distance (air line) between San Isidro de Curuguaty and Ciudad del Este is approximately 99 miles respectively 159 kilometers.
By car or train, the actual journey to Ciudad del Este is certainly longer, as only the direct route (as the crow flies) between San Isidro de Curuguaty and Ciudad del Este has been calculated here.
Air line (approximately)
159 kilometers
86 nautical miles