The calculated distance (air line) between San Isidro de Curuguaty and San Juan Bautista is approximately 177 miles respectively 285 kilometers.
By car or train, the actual journey to San Juan Bautista is certainly longer, as only the direct route (as the crow flies) between San Isidro de Curuguaty and San Juan Bautista has been calculated here.
Air line (approximately)
285 kilometers
154 nautical miles