The calculated distance (air line) between Topes de Collantes and Sancti Spíritus is approximately 37 miles respectively 60 kilometers.
By car or train, the actual journey to Sancti Spíritus is certainly longer, as only the direct route (as the crow flies) between Topes de Collantes and Sancti Spíritus has been calculated here.
Air line (approximately)
60 kilometers
32 nautical miles