The calculated distance (air line) between Topes de Collantes and Guanabacoa is approximately 168 miles respectively 270 kilometers.
By car or train, the actual journey to Guanabacoa is certainly longer, as only the direct route (as the crow flies) between Topes de Collantes and Guanabacoa has been calculated here.
Air line (approximately)
270 kilometers
146 nautical miles