The calculated distance (air line) between Topes de Collantes and Güira de Melena is approximately 170 miles respectively 274 kilometers.
By car or train, the actual journey to Güira de Melena is certainly longer, as only the direct route (as the crow flies) between Topes de Collantes and Güira de Melena has been calculated here.
Air line (approximately)
274 kilometers
148 nautical miles