The calculated distance (air line) between Issa and Nizhniy Novgorod is approximately 173 miles respectively 279 kilometers.
By car or train, the actual journey to Nizhniy Novgorod is certainly longer, as only the direct route (as the crow flies) between Issa and Nizhniy Novgorod has been calculated here.
Air line (approximately)
279 kilometers
150 nautical miles