The calculated distance (air line) between Santa Cruz de Tenerife and Guía de Isora is approximately 37 miles respectively 59 kilometers.
By car or train, the actual journey to Guía de Isora is certainly longer, as only the direct route (as the crow flies) between Santa Cruz de Tenerife and Guía de Isora has been calculated here.
Air line (approximately)
59 kilometers
32 nautical miles