The calculated distance (air line) between La Orotava and Guía de Isora is approximately 20 miles respectively 32 kilometers.
By car or train, the actual journey to Guía de Isora is certainly longer, as only the direct route (as the crow flies) between La Orotava and Guía de Isora has been calculated here.
Air line (approximately)
32 kilometers
17 nautical miles