The calculated distance (air line) between Enschede and Alphen aan den Rijn is approximately 95 miles respectively 153 kilometers.
By car or train, the actual journey to Alphen aan den Rijn is certainly longer, as only the direct route (as the crow flies) between Enschede and Alphen aan den Rijn has been calculated here.
Air line (approximately)
153 kilometers
83 nautical miles