The calculated distance (air line) between 's-Hertogenbosch and Amsterdam-Zuidoost is approximately 44 miles respectively 71 kilometers.
By car or train, the actual journey to Amsterdam-Zuidoost is certainly longer, as only the direct route (as the crow flies) between 's-Hertogenbosch and Amsterdam-Zuidoost has been calculated here.
Air line (approximately)
71 kilometers
39 nautical miles