The calculated distance (air line) between Casalnuovo di Napoli and Perugia is approximately 182 miles respectively 293 kilometers.
By car or train, the actual journey to Perugia is certainly longer, as only the direct route (as the crow flies) between Casalnuovo di Napoli and Perugia has been calculated here.
Air line (approximately)
293 kilometers
158 nautical miles