The calculated distance (air line) between Reggio Calabria and Mazara del Vallo is approximately 170 miles respectively 274 kilometers.
By car or train, the actual journey to Mazara del Vallo is certainly longer, as only the direct route (as the crow flies) between Reggio Calabria and Mazara del Vallo has been calculated here.
Air line (approximately)
274 kilometers
148 nautical miles