The calculated distance (air line) between Città di Castello and Reggio nell'Emilia is approximately 117 miles respectively 188 kilometers.
By car or train, the actual journey to Reggio nell'Emilia is certainly longer, as only the direct route (as the crow flies) between Città di Castello and Reggio nell'Emilia has been calculated here.
Air line (approximately)
188 kilometers
101 nautical miles