The calculated distance (air line) between Casalecchio di Reno and Perugia is approximately 109 miles respectively 176 kilometers.
By car or train, the actual journey to Perugia is certainly longer, as only the direct route (as the crow flies) between Casalecchio di Reno and Perugia has been calculated here.
Air line (approximately)
176 kilometers
95 nautical miles