The calculated distance (air line) between Tupiza and Libertador General San Martín is approximately 174 miles respectively 280 kilometers.
By car or train, the actual journey to Libertador General San Martín is certainly longer, as only the direct route (as the crow flies) between Tupiza and Libertador General San Martín has been calculated here.
Air line (approximately)
280 kilometers
151 nautical miles