The calculated distance (air line) between Avignon and Vaison-la-Romaine is approximately 24 miles respectively 39 kilometers.
By car or train, the actual journey to Vaison-la-Romaine is certainly longer, as only the direct route (as the crow flies) between Avignon and Vaison-la-Romaine has been calculated here.
Air line (approximately)
39 kilometers
21 nautical miles