The calculated distance (air line) between Vaison-la-Romaine and Grenoble is approximately 72 miles respectively 116 kilometers.
By car or train, the actual journey to Grenoble is certainly longer, as only the direct route (as the crow flies) between Vaison-la-Romaine and Grenoble has been calculated here.
Air line (approximately)
116 kilometers
63 nautical miles