The calculated distance (air line) between Rouen and Issy-les-Moulineaux is approximately 68 miles respectively 110 kilometers.
By car or train, the actual journey to Issy-les-Moulineaux is certainly longer, as only the direct route (as the crow flies) between Rouen and Issy-les-Moulineaux has been calculated here.
Air line (approximately)
110 kilometers
59 nautical miles