The calculated distance (air line) between Lille and Issy-les-Moulineaux is approximately 130 miles respectively 209 kilometers.
By car or train, the actual journey to Issy-les-Moulineaux is certainly longer, as only the direct route (as the crow flies) between Lille and Issy-les-Moulineaux has been calculated here.
Air line (approximately)
209 kilometers
113 nautical miles