The calculated distance (air line) between Annecy-le-Vieux and Grenoble is approximately 55 miles respectively 89 kilometers.
By car or train, the actual journey to Grenoble is certainly longer, as only the direct route (as the crow flies) between Annecy-le-Vieux and Grenoble has been calculated here.
Air line (approximately)
89 kilometers
48 nautical miles