The calculated distance (air line) between Popayán and Guadalajara de Buga is approximately 103 miles respectively 166 kilometers.
By car or train, the actual journey to Guadalajara de Buga is certainly longer, as only the direct route (as the crow flies) between Popayán and Guadalajara de Buga has been calculated here.
Air line (approximately)
166 kilometers
90 nautical miles