The calculated distance (air line) between Medellín and Guadalajara de Buga is approximately 170 miles respectively 274 kilometers.
By car or train, the actual journey to Guadalajara de Buga is certainly longer, as only the direct route (as the crow flies) between Medellín and Guadalajara de Buga has been calculated here.
Air line (approximately)
274 kilometers
148 nautical miles