The calculated distance (air line) between L'Isle-sur-la-Sorgue and Marseille is approximately 46 miles respectively 74 kilometers.
By car or train, the actual journey to Marseille is certainly longer, as only the direct route (as the crow flies) between L'Isle-sur-la-Sorgue and Marseille has been calculated here.
Air line (approximately)
74 kilometers
40 nautical miles