The calculated distance (air line) between L'Isle-sur-la-Sorgue and Grenoble is approximately 93 miles respectively 150 kilometers.
By car or train, the actual journey to Grenoble is certainly longer, as only the direct route (as the crow flies) between L'Isle-sur-la-Sorgue and Grenoble has been calculated here.
Air line (approximately)
150 kilometers
81 nautical miles