The calculated distance (air line) between L'Isle-sur-la-Sorgue and Clermont-Ferrand is approximately 161 miles respectively 258 kilometers.
By car or train, the actual journey to Clermont-Ferrand is certainly longer, as only the direct route (as the crow flies) between L'Isle-sur-la-Sorgue and Clermont-Ferrand has been calculated here.
Air line (approximately)
258 kilometers
139 nautical miles