The calculated distance (air line) between San Sebastián de Mariquita and Medellín is approximately 86 miles respectively 139 kilometers.
By car or train, the actual journey to Medellín is certainly longer, as only the direct route (as the crow flies) between San Sebastián de Mariquita and Medellín has been calculated here.
Air line (approximately)
139 kilometers
75 nautical miles