The calculated distance (air line) between San Sebastián de Mariquita and Manizales is approximately 44 miles respectively 71 kilometers.
By car or train, the actual journey to Manizales is certainly longer, as only the direct route (as the crow flies) between San Sebastián de Mariquita and Manizales has been calculated here.
Air line (approximately)
71 kilometers
38 nautical miles