The calculated distance (air line) between San Sebastián de Mariquita and Itagüí is approximately 84 miles respectively 135 kilometers.
By car or train, the actual journey to Itagüí is certainly longer, as only the direct route (as the crow flies) between San Sebastián de Mariquita and Itagüí has been calculated here.
Air line (approximately)
135 kilometers
73 nautical miles