The calculated distance (air line) between Neu-Isenburg and Großzschocher is approximately 181 miles respectively 291 kilometers.
By car or train, the actual journey to Großzschocher is certainly longer, as only the direct route (as the crow flies) between Neu-Isenburg and Großzschocher has been calculated here.
Air line (approximately)
291 kilometers
157 nautical miles