The calculated distance (air line) between Essen and Ludwigshafen am Rhein is approximately 150 miles respectively 242 kilometers.
By car or train, the actual journey to Ludwigshafen am Rhein is certainly longer, as only the direct route (as the crow flies) between Essen and Ludwigshafen am Rhein has been calculated here.
Air line (approximately)
242 kilometers
131 nautical miles