The calculated distance (air line) between Eggenstein-Leopoldshafen and Wuppertal is approximately 160 miles respectively 257 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Eggenstein-Leopoldshafen and Wuppertal has been calculated here.
Air line (approximately)
257 kilometers
139 nautical miles