The calculated distance (air line) between Hachiōji and Yotsukaidō is approximately 47 miles respectively 76 kilometers.
By car or train, the actual journey to Yotsukaidō is certainly longer, as only the direct route (as the crow flies) between Hachiōji and Yotsukaidō has been calculated here.
Air line (approximately)
76 kilometers
41 nautical miles