The calculated distance (air line) between Waldshut-Tiengen and Wiesbaden is approximately 170 miles respectively 273 kilometers.
By car or train, the actual journey to Wiesbaden is certainly longer, as only the direct route (as the crow flies) between Waldshut-Tiengen and Wiesbaden has been calculated here.
Air line (approximately)
273 kilometers
148 nautical miles