The calculated distance (air line) between Vaihingen an der Enz and Wuppertal is approximately 179 miles respectively 289 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Vaihingen an der Enz and Wuppertal has been calculated here.
Air line (approximately)
289 kilometers
156 nautical miles