The calculated distance (air line) between Rüdesheim am Rhein and Wuppertal is approximately 95 miles respectively 152 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Rüdesheim am Rhein and Wuppertal has been calculated here.
Air line (approximately)
152 kilometers
82 nautical miles