The calculated distance (air line) between Rottenburg an der Laaber and Karlsruhe is approximately 166 miles respectively 267 kilometers.
By car or train, the actual journey to Karlsruhe is certainly longer, as only the direct route (as the crow flies) between Rottenburg an der Laaber and Karlsruhe has been calculated here.
Air line (approximately)
267 kilometers
144 nautical miles