The calculated distance (air line) between Rothenburg ob der Tauber and Wiesbaden is approximately 99 miles respectively 160 kilometers.
By car or train, the actual journey to Wiesbaden is certainly longer, as only the direct route (as the crow flies) between Rothenburg ob der Tauber and Wiesbaden has been calculated here.
Air line (approximately)
160 kilometers
86 nautical miles